Methods in population genomics

Ongoing project

There are many methods in population genomics. To help newcomers, we published a review on the main methods in the field, available here

This simple graph should explain it all…

Methods are interconnected, and there are attempts to incorporate this connectivity in more recent works (e.g. machine learning). Aspects that require 'back-and-forth' are indicated by double arrows. Results obtained from methods listed in different sections can be used to inform the next steps of an analysis (single arrows). There is no one-size-fits-all pipeline, and elements of this general framework may be entirely omitted from an analysis depending on the research question.

A few more resources.

I try to regularly update the tables so they reflect the most recent methods. You can also check the blog posts, where I pin reviews or articles that summarize recent methods.

I also design lectures and workshops in population genomics. I recently contributed with Thibault Leroy to an online Physalia course.

In collaboration with Julie Orjuela at IRD, we designed a three-days workshop on population genomics. It is inspired by the one designed for Physalia, but also includes new material, particularly for demographic inference. Data for workshops #1 and #2 can be found at this address

Workshop #1: Population structure

Workshop #2: Demographic inference, introduction to ABC and likelihood approaches

Workshop #3: Selection and association scans

I am also planning another set of workshops on spatial genomics. I recently started developing pipelines using slendr, which is a R package interacting with tskit and SLiM, and can be very useful if your research has a spatial component and you want to test the robustness of your analyses. I will post it here once done.

Table 1: Summary of methods dedicated to infer population structure.

Software Class of method Purpose Class of method Issues/Warnings Reference Link

Table 2: Summary of methods dedicated to detect selection

Software Class of method Purpose Class of method Issues/Warnings Reference Link

Table 3: Summary of methods dedicated to reconstruct demographic history

Software Class of method Purpose Class of method Issues/Warnings Reference Link

Table 4: Summary of simulators and simulation-based methods for selection and demographic inference.

Software Class of method Purpose Class of method Issues/Warnings Reference Link